THE DIPHASIC NATURE OF TUBERCULOSIS IN RABBITS AFTER INTRAVENOUS INOCULATION WITH BOVINE TUBERCLE BACILLI
نویسندگان
چکیده
منابع مشابه
The Diphasic Nature of Tuberculosis in Rabbits after Intravenous Inoculation with Bovine Tubercle Bacilli
It has been shown that in a large group of rabbits inoculated intravenously with bovine tubercle bacilli the disease which follows resolves itself into two distinct phases. The first phase manifests itself in widespread diffuse lesions which subsequently regress. The mortality rate shows a rise and fall during this period, which have been correlated with the extent of lesions and with the chang...
متن کاملThe Resistance of Rabbits to Tuberculosis after Vaccination with Partially Defatted Tubercle Bacilli
1. A vaccine prepared from partially defatted bovine tubercle bacilli influenced favorably the survival time after inoculation with living virulent bovine tubercle bacilli. 2. Accompanying this increased resistance was a sustained lymphocytosis in the vaccinated animals. 3. The vaccine induced a transitory anemia and leucopenia. 4. A similar preparation of partially defatted human tubercle baci...
متن کاملThe Relation of Monocytes and Clasmatocytes to Early Infection in Rabbits with Bovine Tubercle Bacilli
1. The early reaction to intravenous tubercular infection in the various organs of the rabbit reveals a pathognomonic response in the lungs within 24 hours; the specific response in the liver, spleen, lymph glands, and bone marrow, follows from the 6th to the 14th days. 2. The development and extent of the pathologic process has been analyzed in terms of the activity of monocytes and clasmatocy...
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From the foregoing description it is evident that when rabbits are inoculated intravenously with equal amounts of tubercle bacilli of bovine and human type respectively, they are subject to an immediate reaction in the form of an interstitial pulmonary exudation, which, being of equal severity and character does not serve to distinguish the type. There is an hyperplasia of the lymphoid tissue w...
متن کاملHazards of bovine tuberculosis as a matter of public health significance and potential human lung infections with bovine tubercle bacilli.
Following discovery of the tubercle bacilli by Professor Koch, three types of the organisms were soon recognized immunologically as separate and distinct entities, i.e., the human, bovine and avian. For several years thereafter, Koch, as well as many other reputable scientists in the field of bacteriology, contended that the host-species in each category would not contract tuberculosis when exp...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1932
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.56.2.185